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KMID : 0357920130470030293
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Korean Journal of Pathology
2013 Volume.47 No. 3 p.293 ~ p.298
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Case of Multifocal Papillary Thyroid Carcinoma Consisting of One Encapsulated Follicular Variant with BRAF K601E Mutation and Three Conventional Types with BRAF V600E Mutation
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Kim Wook-Youn
Ko Young-Sin
Hwang Tae-Sook
Han Hye-Seung
Lim So-Dug
Kim Wan-Seop
Oh Seo-Young
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Abstract
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Multifocal papillary thyroid carcinoma (mPTC) comprises about 20-30% of PTC. In mPTC, individual tumor foci can be identical or frequently composed of different histological types including follicular, solid, tall-cell or conventional patterns. We report a case of mPTC consisting of one encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) and three conventional PTCs in a 44-year-old woman. This case genetically demonstrates unique features including the simultaneous presence of the BRAF V600E (T1799A) mutation and the BRAF K601E (A1801G) mutation in conventional PTC and FVPTC, respectively.
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KEYWORD
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Thyroid gland, Carcinoma, papillary, BRAF V600E, BRAF K601E
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